Rattanawong W, Akaratanawat W, Tepmongkol S, Chutinet A, Tantivatana J, Suwanwela NC. We propose that pain related to vaccine injection, component of vaccine, such as aluminum, or inflammation related to vaccination might trigger migraine aura in susceptible patients.ĬOVID-19 CoronaVac vaccine Cortical spreading depression Neurological deficit Sinovac. The characteristic sensory symptoms, history of migraine, female predominant, and abnormal functional brain imaging without structural changes suggest migraine aura as pathophysiology. Here, we present a case series of transient focal neurological syndrome following Coronavac vaccination. None developed permanent deficits or structural brain injury. All patients showed moderately large regions of hypoperfusion and concurrent smaller regions of hyperperfusion on SPECT imaging while symptomatic. Magnetic resonance imaging of the brain during and after the attacks did not demonstrate any abnormalities suggesting ischemic stroke. Migraine headache occurred in half of the patients. All presented with lateralized sensory deficits, motor deficits, or both, of 2-14 day duration. Acute onset of focal neurological symptoms occurred within the first 24 h after vaccination in 75% and between 1-7d in 25%. Patients were aged 24-48 years and 75% were female. We report 8 patients with focal neurological symptoms after receiving inactivated virus vaccine, CoronaVac. 15 Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.Īfter the initiation of the COVID-19 vaccination program in Thailand, thousands of patients have experienced unusual focal neurological symptoms.14 Golden Jubilee Medical Center, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.13 Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.12 Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.11 Chulalongkorn Stroke Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. 10 Department of Medicine, Faculty of Medicine, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand. 9 Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Bangkok, 10330, Thailand.8 Chulalongkorn University Biomedical Imaging Group (CUBIG), Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.7 Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.6 Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.5 Chula Neuroscience Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.4 Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Bangkok, 10330, Thailand. 3 Chulalongkorn Stroke Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. 2 Chula Neuroscience Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. 1 Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Bangkok, 10330, Thailand.
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